MMBioS Center Renewed Five More Years

The Biomedical Technology and Research Resource (BTRR) on High Performance Computing for Multiscale Modeling of Biological Systems (MMBioS) was renewed for 5 years by NIH’s National Institute of General Medical Sciences (NIGMS).

MMBioS is a joint effort between the University of Pittsburgh (lead institution, PI: Dr. Ivet Bahar), Carnegie Mellon U (CMU), the Pittsburgh Supercomputing Center (PSC), and the Salk Institute for Biological Studies (Salk). The mission of the Center is to develop methods and software tools to advance research and training at the interface between computing technology and life sciences.

The Center has 4 ongoing Technology & Research Projects, on Molecular Modeling, Cell Simulations, Network Modeling and Bioimage Modeling, led by the Bahar (Pitt), Sejnowski (Salk), Faeder (Pitt), and Murphy (CMU) labs, respectively.

For more information on the Center, visit: www.mmbios.org

Koes CTSI Biomedical Modeling Pilot Award

Congratulations to David Koes and his collaborator Partha Roy! Their proposal to study small molecule inhibition of profilin was funded by CTSI.

Summary:

Our specific aim is to combine computationally-driven rational design with functional assays to discover potent and drug-like small molecules that interfere with the binding of profilin to actin and have anti-migratory and anti-angiogenic effects on endothelial cells. Successful completion of the proposed study will potentially translate to novel therapies for angiogenesis-associated diseases such as diabetic retinopathy, cancer, atherosclerosis, and arthritis.

CSB Members Celebrate the Eclipse

The department celebrated the solar eclipse on Monday, August 21st with eclipse-themed snacks: moon pies, starbursts, eclipse gum, milky ways, and sun chips. We watched the eclipse move to 80% totality with our snappy Bill Nye glasses!

Strong CSB Presence at the 18th International Conference on Systems Biology

Several members of the Department of Computational and Systems Biology participated in the 18th International Conference on Systems Biology.

Dr. Jianhua Xing delivered a plenary talk titled:  “Multi-objective Optimization in Biology and Biomedicine”

Members of the Lezon and Xing labs also gave four contributed talks and a number of posters.

The next conference will be hold at Lyon, France in year 2018. More info can be found here: http://www.cpe.vt.edu/icsb2017/welcome.html

The conference Twitter page can be found here: https://twitter.com/ICSB2017.