The newly launched Computational Biomedicine and Biotechnology (COBB) Master’s program generates leaders who can translate cutting-edge computational technologies into real-world advances in biomedicine and biotechnology. Seated in the Department of Computational and Systems Biology, the program focuses on the interface between computer science and applied biology. It is appropriate for students with backgrounds in either quantitative disciplines (computer science, engineering) or biological sciences and who seek to have an impact in the rapidly evolving field of computational biotechnology. Students in the COBB program will learn to develop and apply novel computational, mathematical, statistical, and in silico techniques to meet current challenges in biotechnology. Our trainees will be equipped with the necessary skills for successful biomedical data science and biocomputing technology careers in the health care and biotechnology industry, government, and academia.