Carlos Camacho

Carlos Camacho, Ph.D.
Associate Professor

Ph.D. in Physics, University of Maryland, College Park

Phone: (412)648-7776

Research Summary

A striking set of specific and non-specific interactions encoded in the protein structure tolerates binding only to a unique substrate. My main research interests focus on modeling the physical interactions responsible for molecular recognition, and in the development of new technologies for structural prediction, their substrates and supramolecular assemblies. Any progress in these fundamental problems is bound to bring about a better understanding of how proteins work cooperatively in a cell, promoting breakthroughs in every aspect of the biological sciences.

Recent Publications
Pabon NA, Zhang Q, Cruz JA, Schipper DL, Camacho CJ, Lee REC (2019) A network-centric approach to drugging TNF-induced NF-κB signaling Nature Communications. 10: 860

Ye Z, Needham PG, Estabrooks SK, Whitaker SK, Garcia BL, Misra S, Brodsky JL, Camacho CJ (2017) Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase. Sci Rep. 7(1): 1789

Pabon NA, Camacho CJ (2017) Probing protein flexibility reveals a mechanism for selective promiscuity. eLife. 6: pii: e22889  

Project title Proj Start Date Proj End Date Funding Source
Spatial Segregation of Cell Functioning during Motility 3/1/2012 11/30/2019 NIGMS-R01
Structural basis of self-recognition in hydroid allorecognition proteins 3/1/2016 2/28/2019 NSF
Realtime Discovery of Inhibitors among Billion Compounds for Preview and Download 3/15/2017 2/28/2021 NIH-R01