Increasingly complex biological problems and extremely large biological data sets have necessitated new approaches to answer many of today’s current research challenges and tackle emerging questions in biology not amenable to traditional approaches.  As one of the fields in the “New Biologies”, Computational and Systems Biology (CSB) encompasses an interdisciplinary approach that harnesses the power of computation and systems-level analyses to formulate and solve critical biological problems.  These research programs within CSB also synergize and collaborate with the extensive basic and clinical research programs at the University of Pittsburgh and across the globe.  Concomitant with our research foci, CSB is also a leader in educating and training all levels of emerging and nascent scientists, who will continue this work and identify and tackle new biological problems of the next generation.

From Dean Shekhar: I am pleased to announce that Frederick P. (Fritz) Roth, PhD, known worldwide for his work in computational biology and genomics, will join the School of Medicine as professor and chair of the Department of Computational and Systems Biology (CSB), effective October 1, 2023. Dr. Roth will also lead the development of the sc...

From the Senior Vice Chancellor for the Health Sciences: “I’m excited to share that preliminary data from the National Institutes of Health (NIH) on grants awarded during federal fiscal year 2022 (FFY22) indicate that funding to the University of Pittsburgh School of Medicine has increased to an estimated $550M—a projected rise of nearly $75M...

Message from the Dean Ivet Bahar, PhD, founding chair of the Department of Computational and Systems Biology (CSB), will be resigning from her role effective December, 31, 2022 after 21 years of exceptional service. Ivet also holds the John K. Vries Chair in Computational Biology, has served as associate director of the University of Pittsburgh Dru...

Combination of Dynamical Systems Theory and Machine Learning Predicts Cell Fate Governing Equations Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, however, requires kinetic models capable of unveiling... (read more)

Carvunis Lab Highlighted for Faculty-Postdoc Relationship Best Practices by Science
The Carvunis Lab was highlighted in an article in Science for their outstanding relationship-building between faculty and postdocs...
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Article in The Atlantic highlights the work of the Bahar lab on MIS-C caused by SARS-CoV-2
This article highlights the work of the Bahar lab in collaboration with the Arditi lab on the molecular origin of multisystem inflammatory syndrome in children (MIS-C) observed in Covid-19... (read more)

Lee Lab Publishes in Science Advances
A myriad of inflammatory cytokines regulate signaling pathways to maintain cellular homeostasis. The IkB kinase (IKK) complex is an integration hub for cytokines that govern nuclear factor kB (NF-kB) signaling. In response to inflammation, IKK is activated through recruitment to receptor-associated protein assemblies... (read more)

Jianhua Xing Promoted to Professor
Congratulations to Dr. Jianhua Xing for his promotion to Professor!
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David Koes Promoted to Associate Professor
Congratulations to Dr. David Koes for his promotion to Associate Professor!
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NSF Graduate Research Fellowship Program offers awards to Caroline Larkin, April Rich and Gaby Gerlach
The 2021 NSF Graduate Research Fellowship Program (GRFP) has offered awards to Caroline Larkin (Faeder/Shoemaker Labs) and April Rich (Carvunis Lab), while Gaby Gerlach (Camacho Lab) has received an honorable mention. Congratulations! (read more)