Maria Chikina

Maria Chikina, Ph.D.
Assistant Professor

Ph.D. in Molecular Biology, Princeton University
Chikina (2)-001

3501 Fifth Avenue
3078 Biomedical Science Tower 3
Pittsburgh, PA 15213


Research Summary

The rise of genome-scale experimental methods has greatly accelerated the speed of biological data accumulation. However, as datasets increase in size, it becomes easier to find patterns and correlations, but harder to distinguish true biological insight from technological and statistical artifacts. Consequently, exploiting large-scale datasets to inform our understanding of biological systems remains a challenge. My work has focused on bridging the gap between statistically rigorous computational techniques and knowledge of underlying biological and experimental processes to develop methods that overcome the biases and artifacts inherent in the structure of large-scale datasets and transform noisy data into concrete biological knowledge.

Recent Publications

Weisel FJ, Zuccarino-Catania GV, Chikina M, Shlomchik MJ (2016) A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells Immunity 44(1):116-30.

Chikina M, Robinson JD, Clark NL (2016) Hundreds of Genes Experienced Convergent Shifts in Selective Pressure in Marine Mammals Mol Biol Evol. Jun 21. pii: msw112. [Epub ahead of print].

Tao J, Xu E, Zhao Y, Singh S, Li X, Couchy G, Chen X, Zucman-Rossi J, Chikina M, Monga SP (2016) Modeling a Human HCC Subset in Mice Through Co-Expression of Met and Point-Mutant β-Catenin Hepatology [Epub ahead of print].

Project title Proj Start Date Proj End Date Funding Source
Separating Wheat from Chaff in Major Depression Blood Biomarker Studies 7/15/2016 6/30/2018 NIMH-R03
Interleukin-35 and the tumor microenvironment 7/1/2016 6/30/2021 NCI-R01
Center for Causal Modeling and Discovery of Biomedical Knowledge from Big Data 9/29/2014 8/31/2018 NHGRI-U54
Yap and beta-catenin interactions in liver: Implications in Pathophysiology 4/5/2016 3/31/2021 NCI-R01
Murine Memory B Cell Development and Function 8/22/2016 7/31/2017 NIH-R01
Transcription Elongation on Bcell Differentiation 3/1/2016 2/28/2018 NIAID-R21