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Maria Chikina

Maria Chikina, Ph.D.
Assistant Professor

Ph.D. in Molecular Biology, Princeton University
Chikina (2)-001

3501 Fifth Avenue
3078 Biomedical Science Tower 3
Pittsburgh, PA 15213


Research Summary

The rise of genome-scale experimental methods has greatly accelerated the speed of biological data accumulation. However, as datasets increase in size, it becomes easier to find patterns and correlations, but harder to distinguish true biological insight from technological and statistical artifacts. Consequently, exploiting large-scale datasets to inform our understanding of biological systems remains a challenge. My work has focused on bridging the gap between statistically rigorous computational techniques and knowledge of underlying biological and experimental processes to develop methods that overcome the biases and artifacts inherent in the structure of large-scale datasets and transform noisy data into concrete biological knowledge.

Recent Publications
Buschur KL, Chikina M, Benos PV (2019) Causal network perturbations for instance-specific analysis of single cell and disease samples Bioinformatics.

Overacre-Delgoffe AE, Chikina M, Dadey RE, Yano H, Brunazzi EA, Shayan G, Horne W, Moskovitz JM, Kolls JK, Sander C, Shuai Y, Normolle DP, Kirkwood JM, Ferris RL, Delgoffe GM, Bruno TC, Workman CJ, Vignali DAA (2017) Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity. Cell. 169(6): 1130-1141

Chikina M, Frieze A, Pegden W (2017) Assessing significance in a Markov chain without mixing. Proc Natl Acad Sci U S A.. 114(11): 2860-2864
Project title Proj Start Date Proj End Date Funding Source
Separating Wheat from Chaff in Major Depression Blood Biomarker Studies 7/15/2016 6/30/2018 NIMH-R03
Interleukin-35 and the tumor microenvironment 7/1/2016 6/30/2021 NCI-R01
Center for Causal Modeling and Discovery of Biomedical Knowledge from Big Data 9/29/2014 8/31/2018 NHGRI-U54
Yap and beta-catenin interactions in liver: Implications in Pathophysiology 4/5/2016 3/31/2021 NCI-R01
Murine Memory B Cell Development and Function 8/22/2016 7/31/2017 NIH-R01
Transcription Elongation on Bcell Differentiation 3/1/2016 2/28/2018 NIAID-R21
Functional Annotation of Genomes via Phenotypic Convergence 5/1/2017 4/30/2022 NIH-R01
PAGES: Physical Activity Genomics, Epigenomics, transcriptomics chemical analysis Site 12/8/2016 11/30/2022 NIH-U24