A research article conducted by Drs. Carlos J. Camacho and Timothy Travers has been published in a recent edition of “the premier journal in cell signaling in physiology and disease,” Science Signaling. The article, “Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function” describes how the phosphorylation of a tyrosine in the disordered N-terminal region of ACTN4 functions as a switch exposing a second site for phosphorylation, important for regulation of the interaction of ACTN4 with actin.
Dr. Travers provided the front cover for the edition, released on May 26th. The image shows the predicted conformations of the N-terminal domain containing the two residues that are phosphorylated.
Read “Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function” online.
Please join us in welcoming this year’s cohort of students:
Rob Bierman (Trinity), Alex Carle (Purdue), Katherine Driscoll (USC), Christine Grassi (Pitt), Natalie Hanisch (Nebraska), Simon Hunt (Kent St), Joycelyne Johnson (St. John’s), Lyle Kingsbury (Hunter), Eric Pederson (CMU), Joseph Robinson (Gettysburg), Ivy Shi (Pitt), Maria Wu (Yale).
Dr. Jeremy Berg and Michelle Keinholz use their collective experience and knowledge of the NIH to help readers navigate the world of grant writing in their book, How the NIH Can Help You Get Funded: An Insider’s Guide to Grant Strategy .
Prior to joining the University of Pittsburgh and our department in 2011, Dr. Berg served as director at the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH) where he oversaw a $2 billion budget for scientific research. Michelle Kienholz is an experienced grant writer and has authored the popular blog, Writeit.
With the present federal spending cuts, How the NIH Can Help You Get Funded provides invaluable information on how to support your research.
(Read more in the Pitt University Times)
Our Joint Carnegie Mellon – University of Pittsburgh Ph.D. Program in Computational Biology (CPCB) was highlighted in the Scientist. The article spoke of the new interdisciplinary environments being created by today’s big data sets generated by high-throughput sequencing and large-scale proteomic screens. Our program spans over 20 departments and 7 Centers/Institutes between CMU and Pitt.
Co-founded in 2005 by Dr. Ivet Bahar and Dr. Robert Murphy, our Ph.D. program was a pioneer in this “new biology,” integrating the quantitative fields with traditional biology. Dr. Dan Zuckerman, associate director of the CPCB program, said, “Biology on the whole is becoming more and more quantitative, and not just from the big-data point of view in terms of genomics, but also in terms of the types of precise measurements that people are doing in the biological world.” (Read more)
Olena, A. (2014, Feb). New School. Retrieved from The Scientist: http://www.thescientist.com/?articles.view/articleNo/38979/title/New-School/
This article in International Innovation highlights the broader scope of Dr. Bahar’s work. She explains her laboratory’s work towards understanding the dynamics of biomolecular and specifically neurosignalling systems.