PhD in Pharmaceutical Chemistry, University of Hamburg

W957 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, Pennsylvania 15261

412-383-5856
avogt@pitt.edu
Office: W 948 BST
Lab Website

Research Summary

One of my current research interests is the expansion of HCS into multicellular organisms. It is becoming increasingly clear that better models of the in vivo milieu are needed to improve the discovery of new drug candidates. Zebrafish, C. elegans, and Drosophila in particular provide unique opportunities to discover novel potential therapeutics using functional assays in a living animal as a complement to cellular and tissue model approaches. Together with members in the Departments of Neurology, Developmental Biology, and the Graduate School of Public Health I have established methodology for zebrafish chemical screening, generated automated image analysis tools for quantification of reporter gene expression, and automated neurobehavioral assays in multiwell plate formats. Current discovery projects include cancer immunology, kidney and heart regeneration, and neurodegenerative diseases.

In my role as a member of the UPDDI leadership faculty at the University of Pittsburgh Drug Discovery Institute I aim to translate outstanding basic discoveries into novel therapeutics by providing advice and support on all aspects of the drug discovery process including target validation, assay development and high throughput screening, and by stimulating and facilitating new drug development applications to funding agencies.

Dr. Vogt is a member of the Editorial Board for SLAS Discovery.