Andreas Vogt

Andreas Vogt, Ph.D.
Associate Professor

Ph.D. in Pharmaceutical Chemistry, University of Hamburg
W 948 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, Pennsylvania 15261
Phone: (412) 383-5856
Fax: (412) 648-9009
Research Summary

One of my current research interests is the expansion of HCS into multicellular organisms. It is becoming increasingly clear that better models of the in vivo milieu are needed to improve the discovery of new drug candidates. Zebrafish, C. elegans, and Drosophila in particular provide unique opportunities to discover novel potential therapeutics using functional assays in a living animal as a complement to cellular and tissue model approaches. Together with members in the Departments of Neurology, Developmental Biology, and the Graduate School of Public Health I have established methodology for zebrafish chemical screening, generated automated image analysis tools for quantification of reporter gene expression, and automated neurobehavioral assays in multiwell plate formats. Current discovery projects include cancer immunology, kidney and heart regeneration, and neurodegenerative diseases.

Recent Publications
Ngo M, Wechter N, Tsai E, Shun T, Gough A, Schurdak M, Schwacha A, Vogt A (2019) A High Throughput Assay for Inhibitors of Defective DNA Replication Based upon Multivariate Analysis of Yeast Growth Kinetics SLAS Discovery. 1: 1-13

Saydmohammed M, Vollmer LL, Onuoha EO, Maskrey TS, Gibson G, Watkins SC, Wipf P, Vogt A, Tsang M (2018) A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development Molecules. 23: 7

Hukriede N, Vogt A, de Cae (2017) Drug Discovery to Halt the Progression of Acute Kidney Injury to Chronic Kidney Disease: A Case for Phenotypic Drug Discovery in Acute Kidney Injury Nephron.
Project title Proj Start Date Proj End Date Funding Source
High-content screening for modulators of lamin B1 as a therapeutic target in autosomal dominant leukodystrophy 04/01/2018 03/31/2021 NIH R33
High content in vivo screening for acute kidney injury ameliorating drugs 01/01/2016 12/31/2019 NIH R01
Development of High-Throughput screening assays for identification of small molecule inhibitors of the Mcm2-7 replicative helicase 01/01/2016 12/31/2019 NIH R01