This web site serves the BioNetGen user community by providing information about BioNetGen and tools for the development, annotation, and discussion of BioNetGen models.

Please send questions, comments, and account requests to We will treat all help requests, including models or model snippets, as confidential.

If you use BioNetGen in a work submitted for publication, please cite:

Harris, L. A. et al. BioNetGen 2.2: advances in rule-based modeling. Bioinformatics 32, 3366–3368 (2016).

In addition, please send us an email or send a tweet to @bionetgen. We’d love to hear about it!


  • RuleBender – the graphical interface for BioNetGen that includes BioNetGen and NFsim source code and executables for Mac, Windows, and Linux. New! Version 2.3 released April, 2019.
  • BioNetGen – command-line only version that includes BioNetGen and NFsim source code plus executables for Mac, Windows, and Linux.

Documentation and Tutorials





Current development of BioNetGen is supported in part by the NIGMS-funded (P41GM103712) National Center for Multiscale Modeling of Biological Systems (MMBioS). Past support has been provided by NIH grants (GM076570, GM103712, GM085273, AI35997, CA109552), NSF grant 0829788, the Arizona Biomedical Research Commission, and the Department of Computational Biology at the University of Pittsburgh School of Medicine.

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