Albert Gough

Albert Gough, Ph.D.
Research Associate Professor

Ph.D. in Biology/Biophysics, Carnegie Mellon University

3501 Fifth Avenue Pittsburgh, PA 15260

Phone: 412-383-5915

Research Summary

My research is focused on relating in vitro cellular systems models to in vivo biological functions. Using automated high content imaging systems we are able to create cellular models with readouts that indicate a wide range of cellular functions. Alterations in function at the tissue, organ and organism level, should be related to alterations in cellular functions. However, the interactions and heterogeneity at the cellular level complicates that relationship. Presently we are building a cellular model in which to analyze cancer pathway interactions and heterogeneity. The goal is to provide an approach to developing therapies that address the fundamental heterogeneity of biological systems.

Recent Publications
Ngo M, Wechter N, Tsai E, Shun T, Gough A, Schurdak M, Schwacha A, Vogt A (2019) A High Throughput Assay for Inhibitors of Defective DNA Replication Based upon Multivariate Analysis of Yeast Growth Kinetics SLAS Discovery. 1: 1-13

Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL (2017) Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep. 7: 42296

Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla SC, Schurdak ME, Haney SA, Taylor DL (2017) Biologically Relevant Heterogeneity: Metrics and Practical Insights. SLAS Discov.. (3): 213-237
Project title Proj Start Date Proj End Date Funding Source
Chemical Biology Consortium – Task Order 8: Administrative Support 02/24/2011 03/31/2016 NIH
A 3D biomimetic liver sinusoid construct for predicting physiology and toxicity 07/01/2014 06/30/2017 NIH UH3
Vanderbilt-Pittsburgh Resource for Organotypic Models for Predictive Toxicology 12 /01/2014 11/30/2018 EPA
TissueCypher Testing for Risk Assessment in Barrett’s Esophagus 7/01/15 6/30/2017 NIH R44
Computational Pathology to Aid the Efficiency and Accuracy of Cancer Diagnoses 11/15/2015 05/15/2016 UPMC