Robin E. C. Lee

Robin E. C. Lee, Ph.D.
Associate Professor

Ph.D. in Cellular and Molecular Medicine, University of Ottawa

3083 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15213

Phone: 412-648-8607

Research Summary

To decide between irreversible cell fates such as growth, differentiation or death, cells process information about their environment through a network of molecular circuits. Our research combines principles of systems and synthetic biology with large-scale data to understand how information flows through these circuits. By observing input-output relationships in the same cell using microfluidics, live-cell dynamics and single-molecule microscopy, we aim to decode the ‘language’ of signaling dynamics and develop mathematical models of information flow with single-cell resolution. Our ultimate goal is to understand how population-level responses emerge from single-cell heterogeneity and to rationally manipulate cell fate decisions in disease.

Recent Publications
Cruz JA, Mokashi CS, Kowalczyk GJ, Guo Y, Zhang Q, Gupta S, Schippper DL, Lee REC (2021) A variable-gain stochastic pooling motif mediates information transfer from receptor assemblies into NF-κB Science Advances. 7:

Mokashi CS, Schippper DL, Qasaimeh MA, Lee REC (2019) A System for Analog Control of Cell Culture Dynamics to Reveal Capabilities of Signaling Networks iScience. 19: 586-596

Pabon NA, Zhang Q, Cruz JA, Schipper DL, Camacho CJ, Lee REC (2019) A network-centric approach to drugging TNF-induced NF-κB signaling Nature Communications. 10: 860


Project title Proj Start Date Proj End Date Funding Source
Deciphering Dynamic Signals in Control of Cell Fate Decisions 9/1/2021 6/30/2026 NIH-NIGMS
Sloan Research Fellow 9/1/2020 8/31/2022 Alfred P. Sloan Foundation
Role of a Novel Mitotic 4E-BP1 Protein Isoform in Cellular Transformation 4/1/2019 3/31/2024 NIH-NCI