Jianhua Xing, Ph.D.
|Ph.D., Theoretical Chemistry, University of California, Berkeley, 2002|
3084 Biomedical Science Tower 3
The Xing lab is interested in the following fundamental questions. How do thousands of molecules species orchestrate temporally and spatially to determine a cell phenotype? How can one regulate and direct cell phenotype? Specifically, the lab currently focuses on Epithelial-to-Mesenchymal Transition (EMT), characterized by loss of cell-cell adhesion and increased cell motility. EMT plays important roles in embryonic development, tissue regeneration, wound healing and pathological processes such as fibrosis in lung, liver, and kidney, and cancer metastasis. The lab studies the coupled gene expression and epigenetic dynamics of EMT.
Xiao-Jun Tian, Hang Zhang, Jens Sannerud, Jianhua Xing (2016) Achieving diverse and monoallelic olfactory receptor selection through dual-objective optimization design Proceedings of the National Academy of Sciences of the United States of America
Jingyu Zhang, Xiao-Jun Tian and Jianhua Xing (2016) Signal transduction pathways of EMT induced by TGF-Beta, SHH, and WNT and their crosstalks J. Clin. Med. 5:41
Zhang J, Tian XJ, Chen YJ, Wang W, Watkins S, Xing J Cells Interpret Temporal Information From TGF-β Through A Nested Relay Mechanism bioRxiv, 134106