Andrew M. Stern, Ph.D.
|Ph.D. in Biological Chemistry, University of California at Los Angeles|
3501 Fifth Avenue
The overarching goal of our research is to identify mechanisms involved in complex human disease progression and use this knowledge to develop novel therapies for individual patients. We apply a holistic clinically relevant quantitative systems biology and pharmacology approach. This involves the development, implementation, and integration of several high throughput and high content molecular and cell-based technologies and models to comprehensively define fundamental biological processes that are perturbed in particular diseases.
Recent PublicationsUttam S, Stern AM, Furman S, Pullara F, Spagnolo D, Nguyen L, Gough AH, Sevinsky C, Ginty F, Taylor DL, Chennubhotla SC (2020) Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks Nature Communications. 11: 3515
Bahreini A, Li Z, Wang P, Levine KM, Tasdemir N, Cao L, Weir HM, Puhalla SL, Davidson NE, Stern AM, Chu D, Park BH, Lee AV, Oesterreich S (2017) Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models. Breast Cancer Res. 19(1): 60
Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla SC, Schurdak ME, Haney SA, Taylor DL (2017) Biologically Relevant Heterogeneity: Metrics and Practical Insights. SLAS Discov.. (3): 213-237