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Mark Schurdak

Mark E. Schurdak, Ph.D.
Visiting Research Associate Professor

Ph.D. in Pharmacology, Baylor College of Medicine
10045 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, Pennsylvania 15260
Phone: 412-648-3090
Research Summary

My research interests center on applying a systems biology/pharmacology approach to develop more effective drug discovery strategies that utilize integrated phenotype/function-based analysis (where all targets involved are functioning in a more physiologic relevant environment) and to better understand the molecular mechanisms that cause drugs to succeed or fail in the clinic.

Recent Publications

Gough A, Stern AM, Maier J, Lezon T, Shun T-Y, Chennubhotla C, Schurdak ME, Haney SA and Taylor DL (2017). Biologically relevant heterogeneity: Metrics and practical insights. SLAS Discovery 22:213-227 PMID: 28231035

D’Aiuto L, Williamson K, Dimitrion P, McNulty J, Brown CE, Dokuburra CB, Nielsen AJ, Lin WJ, Piazza P, Schurdak ME, Wood J, Yolken RH, Kinchington PR, Bloom DC, Nimgaonkar VL. (2017) Comparison of three cell-based drug screening platforms for HSV-1 infection. Antiviral Res 2:136-140.

LaPorte MG, Wang Z, Colombo R, Garzan A, Peshkov VA, Liang M, Johnston PA, Schurdak ME, Sen M, Camarco DP, Hua Y, Pollock NI, Lazo JS, Grandis JR, Wipf P, Huryn DM (2016) Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors Bioorg Med Chem Lett 26(15):3581-5

Project title Proj Start Date Proj End Date Funding Source
Chemical Biology Consortium – Task Order 8: Administrative Support 02/24/2011 03/31/2016 NIH
Cancer Center Support Grant 08/01/2010 07/31/2016 NIH P30
Understudied orphan receptors – novel treatment targets in ovarian cancer 09/01/2013 8/31/2016 US Army
Acute Pancreatitis as a Model to Predict Transition of Systemic Inflammation to Organ Failure in Trauma and Critical Illness 09/01/2013 8/31/2016 US Army
Determining Mechanisms of Disease Progression using Quantitative Systems Pharmacology (QSP) 01/01/2015 12/31/2018 PA Dept of Health