Jeremy Berg

Jeremy Berg, Ph.D.
Professor; Assoc Vice Chancellor, Science Strategy & Planning (HS);Pittsburgh Foundation Professor and Director, Inst for Personalized Medicine

Ph.D. in Chemistry, Harvard University

Phone: (412) 624-1223

Research Summary

Dr. Berg’s research focuses the relationships between the structures and functions of biological molecules. He has made major contributions to understanding how zinc-containing proteins bind to the genetic material DNA or RNA and regulate gene activity. His work, and that of others in the field, has led to the design of metal-containing proteins that control the activity of specific genes. These tailored proteins are valuable tools for basic research on gene function, and such proteins could one day have medical applications in regulating genes involved in diseases, as well. Dr. Berg has also made contributions to our understanding of systems that target proteins to specific compartments within cells and to the use of sequence databases for predicting aspects of protein structure and function. He is currently using computational methods to estimate binding free energies for peptides interacting with targeting receptors.

Recent Publications

Berg JM, Berg WA (2016) No myth: Benefits of breast screening Nature 529(7586):283.

Levine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, Rothman PB, Schwinn DA, Shapiro LJ, Spiegel AM (2015) Research in academic medical centers: Two threats to sustainable support Sci Transl Med. 7(289):289fs22.

Cooper GF, Bahar I, Becich MJ, Benos PV, Berg J, Espino JU, Glymour C, Jacobson RC, Kienholz M, Lee AV, Lu X, Scheines R; Center for Causal Discovery team (2015) The Center for causal discovery of biomedical knowledge from Big Data J Am Med Inform Assoc. (6):1132-6.

Project title Proj Start Date Proj End Date Funding Source
Center for Causal Modeling and Discovery of Biomedical Knowledge from Big Data-Admin 9/29/2014 8/31/2018 NHGRI-U54