A research article conducted by Drs. Carlos J. Camacho and Timothy Travers has been published in a recent edition of “the premier journal in cell signaling in physiology and disease,” Science Signaling. The article, “Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function” describes how the phosphorylation of a tyrosine in the disordered N-terminal region of ACTN4 functions as a switch exposing a second site for phosphorylation, important for regulation of the interaction of ACTN4 with actin.
Dr. Travers provided the front cover for the edition, released on May 26th. The image shows the predicted conformations of the N-terminal domain containing the two residues that are phosphorylated.