Zoltan Oltvai


Zoltan Oltvai, MD
Associate Professor of Pathology

MD, Semmelweiss Medical University, Budapest
3087 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15213
Research Summary

Dr. Oltvai’s research interest is in the area of systems biology of cell metabolism, including the metabolism of prokaryotic and mammalian cells, including tumor cells.

Dr. Oltvai is a staff pathologist in the Division of Clinical Microbiology. He is also a faculty member of the Interdisciplinary Biomedical Science Graduate Program, the Medical Scientist Training Program, the Cellular and Molecular Pathology Graduate Training Program, and the Joint CMU-Pitt PhD Program in Computational Biology.

Recent Publications

Rashid, S.*, Long, Z.*, Singh, S., Kohram, M., Vashistha, H., Navlakha, S., Salman, H., Oltvai, Z.N. and Bar-Joseph, Z., (2019) Adjustment in tumbling rates improves bacterial chemotaxis on obstacle-laden terrains. Proc. Natl. Acad. Sci. U.S.A., 116: 11770-11775

Beckwitt, C.H., Clark, A.M., Ma, B., Whaley, D., Oltvai, Z.N. and Wells, A. (2018) Statins attenuate outgrowth of breast cancer metastases. Br. J. Cancer, 119: 1094–1105.

Singh, M., Warita, K., Warita, T., Faeder, J.R., Lee, R.E.C., Sant, S. and Oltvai, Z.N. (2018) Shift from sto­chastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors. Sci. Rep., 8: 9388

Ishikawa, T., Hosaka, Y.Z., Beckwitt, C.H., Wells, A., Oltvai, Z.N. and Warita, K.  (2018) Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics. Oncotarget, 9: 29304-29315.

Raghu, V., Beckwitt, C.H, Warita, K., Wells, A., Benos, P.V. and Oltvai, Z.N., (2018) Biomarker identifica­tion for statin sensitivity of cancer cell lines. Biochem. Biophys. Res. Comm., 495: 659-665.

Liu, B., Oltvai, Z.N., Bayir, H., Silverman, G.A., Pak, S.C., Perlmutter, D.H. and Bahar, I. (2017) Quanti­tative assessment of cell fate decision between autophagy and apoptosis. Sci. Rep., 7:17605

Long, Z., Quaife B, Salman, H. and Oltvai, Z.N. (2017) Cell-cell communication enhances bacterial chemotaxis toward external attractants. Sci. Rep., 7:12855

PubMed publications