Takis Benos

Panayiotis (Takis) V. Benos, Ph.D.
Professor and Vice Chair of Faculty Affairs

Molecular Biology, University of Crete, 1997
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Contact
Department of Computational and Systems Biology, SOM
University of Pittsburgh, SOM
3501 Fifth Ave., Suite 3064 BST3
Pittsburgh, PA 15260, U.S.A.

Phone: (412) 648-3315
E-mail: benos@pitt.edu
Website: http://www.csb.pitt.edu/Faculty/benos/

Research Summary

Our ultimate goal is to investigate the causes of chronic diseases and cancer by using all available data. Our work involves the development of new machine learning methods for the integration of multi-modal, large, biomedical datasets in a probabilistic graphical framework. For this purpose we collaborate with many clinical researchers in the University of Pittsburgh and elsewhere.

Recent Publications

N. Olave, C.V. Lal, B. Halloran, K. Pandit, A.C. Cuna, O.M. Faye-Petersen, D.R. Kelly, T. Nicola, P.V. Benos, N. Kaminski, N. Ambalavanan, “Regulation of alveolar septation by microRNA-489?, Am J Physiol Lung Cell Mol Physiol, (2016), 10:L476-L487. PMCID:PMC4773841 Editor’s pick

G.F. Cooper, I. Bahar, M.J. Becich, P.V. Benos, J. Berg, J.U. Espino, C. Glymour, R.C. Jacobson, M. Kienholz, A.V. Lee, X. Lu, R.B. Scheines, Center for Causal Discovery team, “The Center for Causal Discovery of biomedical knowledge from Big Data” J Am Med Inform Assoc, (2015), 22:1132-1136. PMID: 26138794

L.C. Villaruz(*), G.T. Huang(*), M. Romkes, J.M. Kirkwood, S.C. Buch, T. Nukui, K.T. Flaherty, S.J. Lee, M.A. Wilson, K.L. Nathanson, P.V. Benos, H.A. Tawbi, “MicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603? Clinical Epigenetics, (2015), 7:58. PMCID:PMC4457092
(*) equal contribution

Grants
Project title Proj Start Date Proj End Date Funding Source
Cell-Specific Transcription in Cancer Microenvironment in vitro and in vivo 7/9/2012 4/30/2017 NCI-R01
Center for Causal Modeling and Discovery of Biomedical Knowledge from Big Data 9/29/2014 8/30/2018 NHGRI-U54
Integrative Graphical Models for Large Multi-Modal Biomedical Data 6/1/2015 5/31/2019 NLM-R01
Integrated Interdisciplinary, inter-university PhD Program Computational Biology (T32) 8/1/2014 7/31/2019 NIBIB-T32
Genomic Analysis of Tissue and Cellular Heterogeneity in IPF 8/14/2015 5/31/2019 NHLBI-R01
Probabilistic Causal Models for Melanoma Therapy Prognosis 3/1/2016 2/28/2017 P01CA121973-08
Vascular Subphenotypes of Lung Disease 5/1/2016 4/30/2017 NIHLB-P01
Integrative Graphical Models for Large Multi-Modal Biomedical Data 6/1/2016 5/31/2019 NLM-R01
Immunoprevention and immunosurveillance of human non-viral cancers 8/1/2016 7/31/2019 NIH-R35