Jianhua Xing

Jianhua Xing, Ph.D.
Associate Professor

Ph.D., Theoretical Chemistry, University of California, Berkeley, 2002
Xing, Jianhua

3084 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15213

Phone: 412-383-5743
E-mail: xing1@pitt.edu
Website: http://www.csb.pitt.edu/Faculty/xing/

Research Summary

The Xing lab is interested in the following fundamental questions. How do thousands of molecules species orchestrate temporally and spatially to determine a cell phenotype? How can one regulate and direct cell phenotype? Specifically, the lab currently focuses on Epithelial-to-Mesenchymal Transition (EMT), characterized by loss of cell-cell adhesion and increased cell motility. EMT plays important roles in embryonic development, tissue regeneration, wound healing and pathological processes such as fibrosis in lung, liver, and kidney, and cancer metastasis. The lab studies the coupled gene expression and epigenetic dynamics of EMT.

Recent Publications

Jianhua Xing and Robin Lee, Putting it all on pigmentation: Heuristics of a bold and stochastic cell fate decision, Science Signaling, 8:fs17 (2015)

Jingyu Zhang*, Xiao-Jun Tian*, Hang Zhang, Elankumaran Subbiah, Jianhua Xing, TGF-β-induced epithelial-to-mesenchymal transition proceeds through step-wise activation of multiple feedback loops, Science Signaling, 7: ra91 (2014). * co-first author.

P. Wang*, C. Song, H. Zhang*, Z. Wu*, X-J Tian*, J. H. Xing, Epigenetic state network approach for describing cell phenotypic transitions, Interface Focus, 4(3): 20130068 (2014).

Project title Proj Start Date Proj End Date Funding Source
Collaborative Research: Modeling the coupling of epigenetic and transcriptional regulation 9/15/2015 8/31/2019 NSF