Dr. Jingyu Zhang from Xing’s lab presented at Multiscale Cell Fate Symposium at UC Irvine. The NSF-Simons Center for Mulitscale Cell Fate Research (CMCF) held their 2018 Inaugural Symposium on October 1-2, 2018. The Symposium focused on emergent properties of cell fate, and provided several opportunities for initiating collaborations between young researchers across disciplines, including a competition of Interdisciplinary Opportunity Award for supporting collaborative projects.
Dr. Maria Chikina and associates contributed to a publication regarding avenues for the treatment of autoimmunity based on selectively exploiting the exhausted phenotype of tissue-infiltrating T cells.
While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, little is known about how T cells function after infiltrating the kidney. The current paradigm suggests that kidney-infiltrating T cells (KITs) are activated effector cells contributing to tissue damage and ultimately organ failure. Herein, we demonstrate that the majority of CD4+ and CD8+ KITs in 3 murine lupus models are not effector cells, as hypothesized, but rather express multiple inhibitory receptors and are highly dysfunctional, with reduced cytokine production and proliferative capacity. In other systems, this hypofunctional profile is linked directly to metabolic and specifically mitochondrial dysfunction, which we also observed in KITs. The T cell phenotype was driven by the expression of an “exhausted” transcriptional signature. Our data thus reveal that the tissue parenchyma has the capability of suppressing T cell responses and limiting damage to self. These findings suggest avenues for the treatment of autoimmunity based on selectively exploiting the exhausted phenotype of tissue-infiltrating T cells.
Click here to view the full publication
SpIntellx has officially launched as a computational pathology company applying its proprietary AI technologies to analyze whole slide images based on spatial analytics. Their mission is to develop tools that will improve the accuracy and efficiency of pathologists and to generate predictive data to optimize patient outcomes.
D. Lansing Taylor, Ph.D.
Chakra Chennubhotla, Ph.D.
Michael Becich, M.D., Ph.D.
Jeffrey Fine, M.D.
Visit the website for more information: spintellx.com
In the News:
Pitt startup leverages Pittsburgh’s dominant role in new age of autonomy
Jintao Liu (Tsinghua University) received a 2018 Outstanding Young Scholar Award at the 2018 Annual Qiu Shi Awards Ceremony this past weekend at the University of Science and Technology of China. A total of twelve young scholars were presented with the award for having made outstanding achievements in areas such as new condensed theoretical physics, new energy materials, algebraic geometry, intestinal immunity and microorganisms.
Jintao Liu received his PhD in Physics under the joint supervision of Drs. Carlos Camacho and James Faeder on the Department of Computational and Systems Biology. His PhD research involved developing functional models of disordered proteins and modeling the kinetics of bacterial spore germination.
Founded in 1994, the primary mission of the Qiu Shi Science and Technology Foundation is to promote scientific and technological progress in China by recognizing and rewarding successful Chinese scientists and scholars.
Congratulations to Dr. Anne-Ruxandra Carvunis for being a recipient of a 2018 Trailblazer Award from the Ladies Hospital Aid Society!