PhD in Biochemistry, UMass Medical School
Research Summary
Dr. Noyes’s research balances systems and synthetic biology, deploying high-throughput assays to understand protein function and design novel proteins for therapeutic applications. His intensive studies of C2H2 zinc finger (ZF) domains have culminated in an AI model of ZF design, which enables genome and epigenetic applications. Dr. Noyes’ group is applying designer ZFs to address Trinucleotide Repeat Diseases, such as Huntington’s Disease, and haploinsufficiencies like Dravet Syndrome, where ZFs have strong potential for clinical use that is more flexible and safe than CRISPR-Cas9.
Dr. Noyes also brings biotech industry experience, as his scientific interests have led to the founding of one company and partnership arrangements with others.