Speaker: Sylvain V. Costes, Ph.D.
Director, Center for Space Biomanufacturing and Synthetic Biology at Trivedi Space Institute
About the Seminar:
“Unlocking the Secrets of Space Biology with Computational Biology”
Spaceflight exposes biology to chronic space radiation, microgravity, and metabolic stress, and understanding how life adapts to these conditions requires multi scale, data driven approaches. In this talk, I will show how computational biology and AI modeling can reveal structure in spaceflight omics and imaging datasets, drawing on insights from NASA repositories and from computational models of cellular and tissue level responses. I will also present results from a GWAS study of approximately 800 healthy participants in which individual variation in DNA damage response to ionizing radiation ex vivo was linked to genomic differences. Finally, I will introduce the Biodigital Triplet, an integrated framework that combines human data, organ on chip systems, and AI digital twins. This platform will support the Center for Space Biomanufacturing and Synthetic Biology that I will lead at Pitt, bringing together investigators in AI, computational biology, and organoid research with the shared goal of creating biological avatars for precision health.
Event Details
- Date: December 15, 2025
- Time: 11:30 a.m. – 12:30 p.m.
- Location: BST3 6014