Andreas Vogt

Andreas Vogt, Ph.D.
Associate Professor

Ph.D. in Pharmaceutical Chemistry, University of Hamburg
10047 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, Pennsylvania 15260
Phone: (412) 383-5856
Research Summary

One of my current research interests is the expansion of HCS into multicellular organisms. It is becoming increasingly clear that better models of the in vivo milieu are needed to improve the discovery of new drug candidates. Zebrafish, C. elegans, and Drosophila in particular provide unique opportunities to discover novel potential therapeutics using functional assays in a living animal as a complement to cellular and tissue model approaches. Together with members in the Departments of Neurology and Developmental Biology I have established methodology for zebrafish chemical screening, generated automated image analysis tools for quantification of reporter gene expression, and automated neurobehavioral assays in multiwell plate formats. Currently active zebrafish discovery projects include fibroblast growth factor signaling, angiogenesis, kidney progenitor cell expansion, early safety assessment, and neurodegenerative diseases.

Recent Publications

Skrypnyk NI, Sanker S, Brilli-Skvarca L, Novitskaya T, Woods C, Chiba T, Patel K, Goldberg ND, McDermott L, Vinson PN, Calcutt MW, Huryn DM,Vernetti LA, Vogt A, Hukriede N, de Caestecker MP (2015) Delayed treatment with PTBA analogs reduces post injury renal fibrosis after kidney injury Am J Physiol Renal Physiol. [Epub ahead of print]

Li M, Yang Z, Vollmer LL, Gao Y, Fu Y, Liu C, Chen X, Liu P, Vogt A, Yin XM (2015) AMDE-1 Is a Dual Function Chemical for Autophagy Activation and Inhibition PLoS One 10(3):e0122083.

George Rosenker KM, Paquette WD, Johnston PA, Sharlow ER, Vogt A, Bakan A, Lazo JS, Wipf P (2015) Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B Bioorg Med Chem 23(12): 2810-8.

Project title Proj Start Date Proj End Date Funding Source
Small Molecule Screens to Identify Probe Sets for the Study of Repair and Regeneration 07/01/2012 06/30/2017 NIH R01
Determining Mechanisms of Disease Progression using Quantitative Systems Pharmacology (QSP) 01/01/2015 12/31/2018 PA Dept of Health