From Hi-C maps to Chromosome Dynamics and Cross-Correlations between Gene Loci
This is the first structure-based study of chromosomal dynamics using elastic network models, between the Bahar and Kingsford labs.
In this study, we constructed Gaussian Network Models (GNM) for chromosome structures based on Hi-C maps. The GNM analysis permits us to predict chromatin mobility profile, identify hierarchical structural domains, and discover cross-correlated distal domains (CCDDs). These biological findings were found consistent with various types of experimental data, including chromatin accessibility (ATAC-seq and DNase-seq), interacting pairs of regulatory elements and gene loci (ChIA-PET), and gene co-expression.
Sauerwald,N.*, Zhang,S.*, Kingsford,C., Bahar, I. (2017) Chromosomal dynamics predicted by an elastic network model explains genome-wide accessibility and long-range couplings. Nucleic Acids Research.
Making a Difference by Daring to be Different: Read about the life and career of Ivet Bahar
- Ivet’s beginning in Turkey, her home country, where she attained her degree and started her academic career
- Her move to the US, where she founded our department and our Ph.D. program
- Her pioneering work on the Gaussian Network Model, which has become an established tool to compute protein dynamics
- Her continued scholarly success both at the University and nationally
- And her advice to young researcher. Here is an excerpt:
Ivet has had several female doctoral students even though women are underrepresented in her area of research. Ivet’s message to young women aspiring to have scientific careers is to be brave and to take risks. Women (as well as men) can do whatever they want but she says that they should not ‘wait’ and hope for the best time, as there may never be one, but just seize the day and do it.
See the Biophysical Society’s Tweet here: https://twitter.com/BiophysicalSoc/status/839181537715322880
Find the article here: http://www.biophysics.org/Portals/1/PDFs/Biophysics%20Week/Profiles/IBahar.pdf
Dr. Koes’s grant, “Methods, Tools and Resources for Interactive Online Virtual Screening and Lead Optimization,” was scored in the top 1% of proposals and selected for renewal by the NIGMS.
The proposed work will accelerate the pace of drug discovery by developing, validating, and testing new methods, tools, and resources for structure-based drug design. Two fundamental challenges of structure-based drug design are the accurate scoring and ranking of protein-ligand structures, which identifies active compounds, and the ability to efficiently search a large number of ligands, which ensures that active compounds are sampled. This proposal will address these challenges by developing a novel approach for protein-ligand scoring and expanding the size of the chemical space that can be efficiently searched during lead optimization. The methods will be validated by their prospective application toward the discovery of new anti-cancer molecules and will be made readily accessible through online resources and open-source tools.
Congratulations to Drs. Bahar, Jernigan, and Dill who published a book with Garland Science titled, Protein Actions.
- Introduces quantitative approaches for studying protein structure and function
- Emphasizes fundamental concepts and theories of protein science
- Gives the full breath of physical principles and bioinformatics and molecular modeling/simulation tools in the field
- Illuminates how proteins act and interact
- Ends with a synopsis on the role of computations in advancing biology
Photo: Dill, Bahar and Jernigan (from left to right) at the celebration held at the Biophysical Society Meeting in New Orleans on February 14, 2017.
TECBio (http://www.tecbioreu.pitt.edu/) is an NSF-funded, 10-week, summer, REU program hosted by the Department of Computational and Systems Biology that provides a challenging graduate-level research experience in computational biology.
Last year, we completed our 7th summer of TECBio and applied for a renewal. We’re very happy to announce that we were awarded 4 more years of the program! We will be funded until 2021.
Thanks to Joseph Ayoob (PI), Chakra Chennubhotla (CO-PI), the rest of Team TECBio, our mentors, and our students for all of their efforts in creating and maintaining a successful undergraduate program. We look forward to the next 4 years of research and training with the future generation of scientists!