Ivet Bahar (Chair)

 

Ivet Bahar, Ph.D.
Distinguished Professor and John K. Vries Chair

Ph.D. in Chemistry, Istanbul Technical Institute; B.S. and M.S. in Chemical Engineering, Bogazici U.
Bahar

Contact

Assistant: Anna Reinhard
Phone: (412) 624-7615
Email: anr189@pitt.edu | bahar@pitt.edu
Website: /Faculty/bahar/index.php

3058 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15213

Research Summary

Our goal is to understand the mechanisms of function biological systems at multiple scale, from molecular to cellular and systems levels. To this aim (1) we develop novel theoretical and computational models and methods using both fundamental theories and methods of physical sciences and engineering, and advances in machine learning to help understand the dynamics of molecular machines, large complexes and assemblies and biomolecular interactions in the cell; (2) use these approaches to advance knowledge of the molecular basis of protein-protein, -drug, -lipid interactions and their implications on cell signaling, regulation, and evolution, and to identify pharmacological targets for modulating or altering these mechanisms; (3) focus on neurotransmitter transport events in the central nervous system, including in particular dopaminergic and glutamatergic signaling, toward elucidating the molecular mechanisms of signaling and regulation, as well as drug addiction development and neurological disorders; (4) analyze the networks of interactions at multiple levels, from individual molecules to gene loci in the chromatin, to multiple proteins in cellular networks, using engineering tools and concepts of chemical reaction kinetics, transport phenomena, statistical mechanics, and stochastics theory, and identify key nodes/targets that dominate the observed behavior; (5) translate our knowledge from molecular-to-cellular computations and/or theoretical modeling to biomedical, clinical and pharmacological applications; and (6) enable the effective dissemination of our tools and training of a new generation of scientists to efficiently use cutting edge methods of physical sciences, engineering and machine learning to advance research and technology development in life sciences.

Recent Publications

Cheng MH, Bahar I. (2019) Monoamine transporters: structure, intrinsic dynamics and allosteric regulation. Nat Struct. & Molec. Biol 26: 545–556. PMID: 31270469 PMCID: 6712983

Zhang S, Li H, Krieger JM, Bahar I. (2019) Shared signature dynamics tempered by local fluctuations enables fold adaptability and specificityMol Biol Evol 36: 2053-2068. PMID: 31028708 PMCID: 6736388

Ponzoni L, Bahar I. (2018) Structural dynamics is a determinant of the functional significance of missense variants. Proc Natl Acad Sci USA 115: 4164-4169. PMID: 29610305 PMCID: 5910821

Publications

Grants
Project title Role Project Dates Funding Source
BTRC on High Performance Computing for Multiscale Modeling of Biological Systems (MMBioS) (PI: Bahar) PI 2012-2022 NIH-NIGMS P41 GM103712
Center for Medical Countermeasures against Radiation (CMCR) Signature-Directed, Sequential Delivery of Radiation Mitigators (PI: Greenberger, UPMC) PI of Comp System Pharmacology Core 2010-2020 NIH-NIAID
U19 AI068021
NIDA Center of Excellence for Computational Drug Abuse Research (CDAR) (PIs: Xie* (Pitt), Bahar (Pitt) and Xing- Carnegie Mellon University) MPI (Xie,* Bahar, and Xing) 2014-2020 NIH – NIDA
P30 DA035778
BD2K (Big Data to Knowledge) Center for Causal Discovery (CCD) (PIs: Cooper* and Bahar, Pitt) MPI (Cooper* and Bahar) 2014-2019 NIH-NHGRI U54 HG008540
New Therapies for Liver Fibrosis and Hyperproliferation in α1-AT Deficiency (PI: Perlmutter, Wash U) PI of Comp Pharmacology Core 2012-2024 NIH-NIDDK P01 DK96990
Controlling Monolysocardiolipin/cytochrome c Peroxidase Complexes in Barth Syndrome (PI’s: Greenberg (Wayne State) and Kagan (Pitt)) co-investigator 2020-2025 NIH-NIGMS R01
Immunosuppression in Acute Lung Injury
(PI: Mallampalli, Ohio State U)
co-investigator 2019-2024 NIH-NHLBI P01 HL114453
Druggable Mitochondrial Targets for Treatment of Cerebral Ischemia (PIs: Clark and Bayir, UPMC) co-investigator 2020-2025 NIH-NINDS
R01
Identification of drug candidates for PTHR (PIs: Bahar and Vilardaga, Pitt) MPI (Bahar* and Vilardaga) 2019-2020 NIH-CTSI Pilot UL1TR001857
Integrated, Interdisciplinary, Comprehensive Inter-University Ph.D. Program in Comp Biol. PIs: Faeder* and Bahar (Pitt), and Bar-Joseph and Russell (CMU) MPI (Faeder,* Bahar, Bar-Joseph, Russell) 2009-2024 NIH-NIBIB T32 EB009403
Allosteric modulation of dopamine transport-Functional and Biochemical Studies (PI: Ole Mortensen, Drexel University) co-investigator 2020-2025 NIH R01

(*) corresponding PI