Chakra Chennubhotla, Ph.D.
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Ph.D. in Computer Science, University of Toronto | |||||||||||||||||||||||||||||||||
ContactPhone: (412)648-7794 |
Research SummaryDeveloping computational models and methods to improve the understanding of major interactions and allosteric mechanisms that underlie the proper functioning of biomolecular systems. In particular (i) developing information-theoretic concepts for determining the probabilistic rates and pathways of information flow in biomolecular systems both within multicomponent structures and at the cellular level (protein-protein interaction networks); and studying the sequence of events possibly induced by information flow; (ii) designing and interpreting FRET based experiments to explore molecular interactions and correlations and assessing their functional implications; and finally (iii) developing novel methods originating from computer vision for analyzing, refining and interpreting biomolecular images in terms of the structure, dynamics and function of the observed systems, focusing on cryo-electron microscopic measurements. Recent PublicationsBenos PV, Tosun BA, Manatakis DV, Vukmirovic M, Nguyen L, Yan X, Hu B, Deluliis G, Woolard T, Maya JD, Homer R, Kaminski N, Chennubhotla CS (2017) Towards Understanding Spatial Lung Tissue Heterogeneity In Idiopathic Pulmonary Fibrosis (IPF) A72. Mechanisms Driving Fibrosis.
Narayanan C, Bernard DN, Bafna K, Choudhary OP, Chennubhotla CS, Agarwal PK, Doucet N (2017) Conformational Motions Impacting Function in an Enzyme Superfamily The FASEB Journal. 31(1 supplement): 762.6 Jones T, Nguyen L, Tosun BA, Chennubhotla CS, Fine JL (2017) Computational Pathology versus Manual Microscopy: Comparison Based on Workflow Simulations of Breast Core Biopsies Laboratory Investigation. 97: 398A Grants
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