Albert Gough, Ph.D.
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Ph.D. in Biology/Biophysics, Carnegie Mellon University | |||||||||||||||||||||||||
Contact3501 Fifth Avenue Pittsburgh, PA 15260 Phone: 412-383-5915 |
Research SummaryMy research is focused on relating in vitro cellular systems models to in vivo biological functions. Using automated high content imaging systems we are able to create cellular models with readouts that indicate a wide range of cellular functions. Alterations in function at the tissue, organ and organism level, should be related to alterations in cellular functions. However, the interactions and heterogeneity at the cellular level complicates that relationship. Presently we are building a cellular model in which to analyze cancer pathway interactions and heterogeneity. The goal is to provide an approach to developing therapies that address the fundamental heterogeneity of biological systems. Recent PublicationsVernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL (2017) Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep. 7: 42296Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla SC, Schurdak ME, Haney SA, Taylor DL (2017) Biologically Relevant Heterogeneity: Metrics and Practical Insights. SLAS Discov.. (3): 213-237 Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL (2017) Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep. 7: 44517 Grants
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