Albert Gough, Ph.D.
|Ph.D. in Biology/Biophysics, Carnegie Mellon University|
3501 Fifth Avenue Pittsburgh, PA 15260
My research is focused on relating in vitro cellular systems models to in vivo biological functions. Using automated high content imaging systems we are able to create cellular models with readouts that indicate a wide range of cellular functions. Alterations in function at the tissue, organ and organism level, should be related to alterations in cellular functions. However, the interactions and heterogeneity at the cellular level complicates that relationship. Presently we are building a cellular model in which to analyze cancer pathway interactions and heterogeneity. The goal is to provide an approach to developing therapies that address the fundamental heterogeneity of biological systems.
Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla SC, Schurdak ME, Haney SA, Taylor DL. (2017) Biologically Relevant Heterogeneity: Metrics and Practical Insights. SLAS Discov. (3):213-237.
Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. (2017) Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep.7:44517.
Lee-Montiel FT, George SM, Gough AH, Sharma AD, Wu J, DeBiasio R, Vernetti LA, Taylor DL. (2017) Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems. Exp Biol Med (Maywood). 1:1535370217703978. [Epub ahead of print]