We are always looking for postdoc/graduate researchers who will potentially work with me and other more experimental biology-oriented members in the lab. Currently my lab has two major research directions, both related to understanding the dynamics of cell phenotypic conversions. Mammalian cells can assume different phenotypes, and studying the dynamics of conversion between different phenotypes emerges as an exciting new field.
- The first project is on analyzing time-lapse single cell images and extracting dynamic information on cell phenotypic conversion for theoretical and computational modeling. My lab has developed a framework for single cell imaging and computational image analysis (e.g., Wang et al., arXiv:1803.10829) to study the conversion dynamics and mechanism. The researcher will collaborate with others on studying various cell differentiation and transdifferentiation (including reprogramming) processes from a new perspective of nonlinear dynamical systems theory.
- The second project is on analyzing time-lapse images of chromosome structure changes during cell phenotype change. My lab is developing a versatile CRSIPR-dCas9 based platform for live cell imaging of multiplex genomic loci. The researcher will analyze the data from perspective of polymer and chemical physics.
If interested, the researcher will have opportunity to perform simple experimental cell biology and imaging studies as well.
With the above, I am especially interested in applicants with background in quantitative biology and biological physics, or computational image analysis (including machine learning). An applicant with quantitative (imaging based) experimental biological physics background will also be favorably considered. Given the multi-disciplinary nature of our research, the most important factor for success in my lab is being able to learn new things quickly.
For application, please send c.v. and a research plan to me at email@example.com. If you are in town, feel free to drop me an email for appointment or just knock the door of my office.
Undergraduate Researchers: My lab has a tradition of working with undergraduate research programs. We encourage students with certain computer simulation/ experimental cell biology experiences to check for possible research opportunities.