Genome folding by multistate motors
Speaker: Geoffrey Fudenberg, University of South Carolina
Loop extrusion constitutes a universal mechanism of genome organization, whereby structural maintenance of chromosomes protein complexes load onto the chromatin fiber and generate DNA loops of increasingly large sizes until their eventual release. In mammalian interphase cells, loop extrusion is performed by the cohesin complex, which is dynamically regulated by the interchange of multiple accessory proteins. Although these regulators bind the core cohesin complex only transiently, their disruption can dramatically alter cohesin dynamics, gene expression, chromosome morphology and contact patterns. In this talk I will present a theory for the molecular interplay of cohesin regulators and the core complex, centered around a multi-state model of loop extrusion.
Event Details
- Date: Monday, October 27
- Time: 11:30 a.m. – 12:30 p.m.
- Location: BST3 6014
About the Speaker
Geoff Fudenberg is an Assistant Professor in the Department of Quantitative and Computational Biology at USC. His work aims to connect molecular-scale mechanisms with their genome-wide consequences, and uses machine-learning and biophysical modeling approaches to decode connections between 3D genome organization and function. For more information, visit: https://fudenberg.team/