Our ultimate goal is to investigate the molecular mechanisms of chronic diseases. We develop new computational methods to model biological processes and mine high-dimensional, multi-modal biomedical data. We are very interested in the effect of gene regulatory networks in disease.
- L.C. Villaruz(*), G.T. Huang(*), M. Romkes, J.M. Kirkwood, S.C. Buch, T. Nukui, K.T. Flaherty, S.J. Lee, M.A. Wilson, K.L. Nathanson, P.V. Benos, H.A. Tawbi, “MicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603″ Clinical Epigenetics, (2015), 7:58. Abstract (PubMed) and pdf. PMID: 26052356 [PubMed] PMCID:PMC4457092. (*) equal contribution
- N. Olave, C.V. Lal, B. Halloran, K. Pandit, A.C. Cuna, O.M. Faye-Petersen, D.R. Kelly, T. Nicola, P.V. Benos, N. Kaminski, N. Ambalavanan, “Regulation of alveolar septation by microRNA-489″, Am J Physiol Lung Cell Mol Physiol, (2016), 10:L476-L487. Abstract (PubMed) and pdf. PMID:26719145 [PubMed] PMCID:PMC4773841. Editor’s pick
- G.F. Cooper, I. Bahar, M.J. Becich, P.V. Benos, J. Berg, J.U. Espino, C. Glymour, R.C. Jacobson, M. Kienholz, A.V. Lee, X. Lu, R.B. Scheines, Center for Causal Discovery team, “The Center for Causal Discovery of biomedical knowledge from Big Data”, J Am Med Inform Assoc, (2015), 22:1132-1136. Abstract (PubMed) and pdf PMID: 26138794
- Grace T. Huang, I. Tsamardinos, V. Raghu, N. Kaminski, P.V. Benos, “T-ReCS: Stable Selection of Dynamically Formed Groups of Features with Application to Prediction of Clinical Outcomes”, Pac Symp Biocomput, (2015), 20:431-442. Abstract (PubMed) and pdf. PMID:25592602 [PubMed] PMCID:PMC4299881.