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Our ultimate goal is to investigate the molecular mechanisms of chronic diseases.  We develop new computational methods to model biological processes and mine high-dimensional, multi-modal biomedical data.  We are very interested in the effect of gene regulatory networks in disease.

 

Recent Work

  1. L.C. Villaruz(*), G.T. Huang(*), M. Romkes, J.M. Kirkwood, S.C. Buch, T. Nukui, K.T. Flaherty, S.J. Lee, M.A. Wilson, K.L. Nathanson, P.V. Benos, H.A. Tawbi, “MicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603″ Clinical Epigenetics, (2015), 7:58. Abstract (PubMed) and pdf.  PMID: 26052356 [PubMed] PMCID:PMC4457092.  (*) equal contribution
  2. N. Olave, C.V. Lal, B. Halloran, K. Pandit, A.C. Cuna, O.M. Faye-Petersen, D.R. Kelly, T. Nicola, P.V. Benos, N. Kaminski, N. Ambalavanan, “Regulation of alveolar septation by microRNA-489″, Am J Physiol Lung Cell Mol Physiol, (2016), 10:L476-L487. Abstract (PubMed) and pdf.  PMID:26719145 [PubMed] PMCID:PMC4773841. Editor’s pick
  3. G.F. Cooper, I. Bahar, M.J. Becich, P.V. Benos, J. Berg, J.U. Espino, C. Glymour, R.C. Jacobson, M. Kienholz, A.V. Lee, X. Lu, R.B. Scheines, Center for Causal Discovery team, “The Center for Causal Discovery of biomedical knowledge from Big Data”, J Am Med Inform Assoc, (2015), 22:1132-1136.  Abstract (PubMed) and pdf   PMID: 26138794
  4. Grace T. Huang, I. Tsamardinos, V. Raghu, N. Kaminski, P.V. Benos, “T-ReCS: Stable Selection of Dynamically Formed Groups of Features with Application to Prediction of Clinical Outcomes”, Pac Symp Biocomput, (2015), 20:431-442. Abstract (PubMed) and pdf.  PMID:25592602 [PubMed] PMCID:PMC4299881.