Qiuhong Zhang, Ph.D.
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| PhD in Pathology & Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan | |
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Research SummaryI earned my MD and Ph.D. degree in Pathology and Pathophysiology from Xiangya School of Medicine in China. After graduation, I joined the University of Pittsburgh focusing on the molecular mechanism of carcinogenesis, tumor biomarker discovery, and target drug screening. Currently, I am interested in how cellular information processing leads to different cell-fate decisions under cytokine stimulation. To study the dynamic regulation of signaling cascades of NF-kB pathway in single cells, I designed and established a series of single/double fluorescence labeling stable cell lines of interested proteins such as IKK and RelA by CRISPR/Cas9 genomic editing. Moreover, I detected and analyzed the quantitative single cell responses to inflammatory signals by conducting 2D/3D single live cell imaging. I am also involved in the image data analysis tool development and collaboration with a number of biologists to study a variety of crucial biological processes related to NF-kB pathway. Recent PublicationsCruz JA, Mokashi CS, Kowalczyk GJ, Guo Y, Zhang Q, Gupta S, Schippper DL, Lee REC (2021) A variable-gain stochastic pooling motif mediates information transfer from receptor assemblies into NF-κB Science Advances. 7:Pabon NA, Zhang Q, Cruz JA, Schipper DL, Camacho CJ, Lee REC (2019) A network-centric approach to drugging TNF-induced NF-κB signaling Nature Communications. 10: 860 Zhang Q, Gupta S, Schipper D, Kowalczyk G, Mancini A, Faeder J, Lee R (2017) NF-κB Dynamics Discriminate between TNF Doses in Single Cells. Cell Systems. 5(6): 638-645 |
