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Koes CTSI Biomedical Modeling Pilot Award

Congratulations to David Koes and his collaborator Partha Roy! Their proposal to study small molecule inhibition of profilin was funded by CTSI.


Our specific aim is to combine computationally-driven rational design with functional assays to discover potent and drug-like small molecules that interfere with the binding of profilin to actin and have anti-migratory and anti-angiogenic effects on endothelial cells. Successful completion of the proposed study will potentially translate to novel therapies for angiogenesis-associated diseases such as diabetic retinopathy, cancer, atherosclerosis, and arthritis.