Dr. Lee’s grant proposal entitled “Deciphering dynamic signals in control of cell fate decisions” has been selected to receive an R35 Outstanding Investigator ‘MIRA’ award from the NIGMS.
PROJECT NARRATIVE
It is an emerging principle that dynamic properties of molecules within a signaling network, such as sub-cellular changes in protein localization or abundance, provide a temporal codes that mediate cellular responses to stimuli. How dynamic molecular signals relay, and process, information is a critical gap in our understanding of how healthy and diseased cells make decisions. Here we propose a hybrid experimental and computational framework to decipher dynamic signals induced by inflammatory factors in single cells, and understand how cells interpret these signals to decide between inflammation, proliferation, or cell death.
Congratulations, Robin!