The paper provides novel evidence on the molecular determinants of the dual function, substrate transport and anion permeation, of excitatory amino acid transporters (EAATs).
It opens avenues toward illuminating how EAATs regulate synaptic transmission and neurological conditions.
This is a collaborative study between the Bahar and Amara (NIH) labs, with key contributions from Drs. Delany Torres-Salazar and Mary Cheng
Cheng MH#, Torres-Salazar D #, Gonzalez-Suarez AD, Amara SG & Bahar I*, “Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters”. eLife, (2017).