Dr. Takis Benos participated in a collaborative study published in Molecular Cell. The study reports the findings of a “hidden” insulin sensor in the disordered region of SIRT1 protein and the mechanism by which Insulin inhibits SIRT1-mediated catabolic gene expression.
Please click here to read the full article.
Dr. Nick Pabon publishes first author paper in PlosCompBio titled: “Predicting protein targets for drug-like compounds using transcriptomics” with Profs. Carlos J. Camacho and Ziv Bar-Joseph.
The paper describes the first method capable of predicting novel drug-target interactions using gene expression profiles. Nick contribution was specially notable in highlighting correlations between profiles indirectly related to the target as the main determinant of physical interactions in the machine learning model.
Read the full paper here
Dr. Maria Chikina and associates contributed to a publication regarding avenues for the treatment of autoimmunity based on selectively exploiting the exhausted phenotype of tissue-infiltrating T cells.
While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, little is known about how T cells function after infiltrating the kidney. The current paradigm suggests that kidney-infiltrating T cells (KITs) are activated effector cells contributing to tissue damage and ultimately organ failure. Herein, we demonstrate that the majority of CD4+ and CD8+ KITs in 3 murine lupus models are not effector cells, as hypothesized, but rather express multiple inhibitory receptors and are highly dysfunctional, with reduced cytokine production and proliferative capacity. In other systems, this hypofunctional profile is linked directly to metabolic and specifically mitochondrial dysfunction, which we also observed in KITs. The T cell phenotype was driven by the expression of an “exhausted” transcriptional signature. Our data thus reveal that the tissue parenchyma has the capability of suppressing T cell responses and limiting damage to self. These findings suggest avenues for the treatment of autoimmunity based on selectively exploiting the exhausted phenotype of tissue-infiltrating T cells.
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Congratulations to Dr. Anne-Ruxandra Carvunis for being a recipient of a 2018 Trailblazer Award from the Ladies Hospital Aid Society!
Lead author Dr. Wynn Meyer, along with the Clark and Chikina Labs, discusses how the loss of the PON1 gene in some marine mammals could leave them vulnerable to pesticides that seep into the sea.