2022

Long-term imaging of individual mRNA molecules in living cells
Y Guo, REC Lee
Cell Reports Methods


2021

A variable-gain stochastic pooling motif mediates information transfer from receptor assemblies into NF-κB
JA Cruz’, CS Mokashi’, GJ Kowalczyk, Y Guo, Q Zhang, S Gupta, DL Schippper, REC Lee
Science Advances

dNEMO: a tool for quantification of mRNA and punctate structures in time-lapse images of single cells
GJ Kowalczyk, JA Cruz, Y Guo, Q Zhang, N Sauerwald, REC Lee
Bioinformatics


2020

SunRISE: long-term imaging of individual mRNA molecules in living cells
Y Guo, REC Lee
bioRxiv

Parallel Tempering with Lasso for Model Reduction in Systems Biology
S Gupta, REC Lee*, JR Faeder*
PLoS Computational Biology (* co-corresponding)


2019

A system for analog control of cell culture dynamics to reveal capabilities of signaling networks
CS Mokashi, DL Schippper, MA Qasaimeh, REC Lee
iScience

Dopamine D2 receptor modulates Wnt expression and control of cell proliferation
F Han, P Konkalmatt, CS Mokashi, M Kumar, Y Zhang, A Ko, Z Farino, L Asico, G Xu, J Gildea, X Zheng, R Felder, REC Lee, PA Jose, I Armando*, Z Freyberg*
Scientific Reports

A network-centric approach to drugging TNF-induced NF-kB signaling
NA Pabon, Q Zhang, JA Cruz, DL Schipper, CJ Camacho*, REC Lee*
Nature Communications (* co-corresponding); recommended by F1000


2018

Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors
M Singh, K Warita, T Warita, JR Faeder, REC Lee*, S Sant*, ZN Oltvai*
Scientific Reports (* co-corresponding)

Evaluation of Parallel Tempering to Accelerate Bayesian Parameter Estimation in Systems Biology
S Gupta*, L Hainsworth, JS Hogg, REC Lee*, JR Faeder*
IEEE, 26th Euromicro International Conference on Parallel, Distributed and Network-based Processing (PDP) (* co-corresponding)

Spatial Stochastic Modeling with MCell and CellBlender
S Gupta, J Czech, R Kuczewski, TM Bartol, TJ Sejnowski, REC Lee, JR Faeder
Quantitative Biology: theory, computational methods, and models (Ed. Brian Munsky, MIT Press)

NF-κB-Chromatin Interactions Drive Diverse Phenotypes by Modulating Transcriptional Noise
VC Wong, VL Bass, ME Bullock, AK Chavali, REC Lee, W Mothes, S Gaudet, K Miller-Jensen
Cell Reports


2017

NF-κB Dynamics Discriminate between TNF Doses in Single Cells
Q Zhang, S Gupta, DL Schipper, GJ Kowalczyk, AE Mancini, JR Faeder, REC Lee
Cell Systems

Demystifying the cytokine network: Mathematical models point the way
PA Morel, REC Lee, JR Faeder
Cytokine


2016

NF-κB signalling and cell fate decisions in response to a short pulse of tumour necrosis factor
REC Lee, MA Qasaimeh, X Xia, D Juncker, S Gaudet
Scientific Reports


2015

Putting it all on pigmentation: Heuristics of a bold and stochastic cell fate decision
J Xing* and REC Lee*
Science Signaling (* co-corresponding)


2014

Fold Change of Nuclear NF-κB Determines TNF-Induced Transcription in Single Cells
REC Lee, SR Walker, K Savery, DA Frank, S Gaudet
Molecular cell

Cell-to-cell variability in cell death: can systems biology help us make sense of it all?
X Xia, MS Owen, REC Lee, S Gaudet
Cell death & disease

Monitoring the Proteostasis Function of the Saccharomyces cerevisiae Metacaspase Yca1
A Shrestha, REC Lee, LA Megeney
Caspases, Paracaspases, and Metacaspases


2013

A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts
JDR Knight, R Tian, REC Lee, F Wang, A Beauvais, H Zou, LA Megeney, AC Gingras, T Pawson, D Figeys, R Kothary
Skeletal Muscle


2010

Metacaspase Yca1 is required for clearance of insoluble protein aggregates
REC Lee, S Brunette, LG Puente, LA Megeney
Proceedings of the National Academy of Sciences


2009

Reconstructing regulatory kinase pathways from phosphopeptide data: a bioinformatics approach
LG Puente, REC Lee, LA Megeney
Phospho-Proteomics


2008

A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics
REC Lee, LG Puente, M Kærn, LA Megeney
PLoS One


2006

Reconstructing the regulatory kinase pathways of myogenesis from phosphopeptide data
LG Puente, S Voisin, REC Lee, LA Megeney
Molecular & Cellular Proteomics


2005

The yeast kinome displays scale free topology with functional hub clusters
REC Lee, LA Megeney
BMC bioinformatics


Robin E. C. Lee on Pubmed