Tim Lezon

Tim Lezon, Ph.D.
Assistant Professor

Ph.D. in Physics, Pennsylvania State University

Phone: (412) 383-8042
Office: W956 BST
E-mail: lezon@pitt.edu
Website: lezonlab.org

Research Summary

My research focuses on identifying disease-specific pathways from phenotypic screens. Non-clonal cellular heterogeneity is a rich source of information on the molecular activity of cellular pathways, and I construct analytical and computational tools for extracting this information. The specific applications that I am focused on are developing targeted therapies for breast cancer, identifying combinations of drugs that will effectively treat Huntington’s disease, and advancing computational pathology through analysis of intratumor heterogeneity.

Recent Publications

Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL (2014) Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery PLoS One 9(7):e102678.

Bakan A, Dutta A, Mao W, Liu Y, Chennubhotla C, Lezon TR, Bahar I (2014) Evol and ProDy for Bridging Protein Sequence Evolution and Structural Dynamics Bioinformatics [Epub ahead of print]

Lezon TR (2012) The effects of rigid motions on elastic network model force constants Proteins . DOI: 10.1002/prot.24014.

Project title Proj Start Date Proj End Date Funding Source
Identification and Characterization of Regulators and Therapeutics of Cancer Signaling Networks 1/1/2013 12/31/2016 PA Dept Hlth
Informatics Tools for Tumor Heterogeneity in Multiplexed Fluorescence Images 05/04/2016 04/30/2019 NIH