Tim Lezon, Ph.D.
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Ph.D. in Physics, Pennsylvania State University | |||||||||||||
ContactPhone: (412) 383-8042 |
Research SummaryMy research focuses on identifying disease-specific pathways from phenotypic screens. Non-clonal cellular heterogeneity is a rich source of information on the molecular activity of cellular pathways, and I construct analytical and computational tools for extracting this information. The specific applications that I am focused on are developing targeted therapies for breast cancer, identifying combinations of drugs that will effectively treat Huntington’s disease, and advancing computational pathology through analysis of intratumor heterogeneity. Recent PublicationsBergman S, Lezon T (2017) Modeling global changes induced by local perturbations to the HIV-1 capsid. J Mol Graphics Modelling. 71: 218-226
Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla SC, Schurdak ME, Haney SA, Taylor DL (2017) Biologically Relevant Heterogeneity: Metrics and Practical Insights. SLAS Discov.. (3): 213-237 Bakan A, Dutta A, Mao W, Liu Y, Chennubhotla CS, Lezon T, Bahar I (2014) Evol and ProDy for bridging protein sequence evolution and structural dynamics Bioinformatics. Grants
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