Robin E. C. Lee

Robin E. C. Lee, Ph.D.
Assistant Professor

Ph.D. in Cellular and Molecular Medicine, University of Ottawa

3083 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15213

Phone: 412-648-8607

Research Summary

To decide between irreversible cell fates such as growth, differentiation or death, cells process information about their environment through a network of molecular circuits. Our research combines principles of systems and synthetic biology with large-scale data to understand how information flows through these circuits. By observing input-output relationships in the same cell using microfluidics, live-cell dynamics and single-molecule microscopy, we aim to decode the ‘language’ of signaling dynamics and develop mathematical models of information flow with single-cell resolution. Our ultimate goal is to understand how population-level responses emerge from single-cell heterogeneity and to rationally manipulate cell fate decisions in disease.

Recent Publications

Lee REC, Walker S, Savery K, Frank D and Gaudet S (2014) Fold-change of nuclear NF-κB determines TNF-induced transcription in single cells Molecular Cell, 53:6.

Xia X, Owen M, Lee REC and Gaudet S (2014) Cell-to-cell variability in cell death: can systems biology help us make sense of it all? Cell Death & Disease, (in press).

Shrestha A, Lee REC, Megeney LA (2014) Monitoring the proteostasis function of the Saccharomyces cerevisiae metacaspase Yca1. in press: Caspases, Paracaspases and Metacaspases (Methods in Molecular Biology), Ed. Peter Bozhkov, Humana Press USA, vol. 1133.

Project title Proj Start Date Proj End Date Funding Source
Deciphering Dynamic Signals in Control of Cell Fate Decisions 9/1/2016 6/30/2021 NIH-NIGMS