Robin E. C. Lee

Robin E. C. Lee, Ph.D.
Assistant Professor

Ph.D. in Cellular and Molecular Medicine, University of Ottawa
Robin Lee

3083 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15213

Phone: 412-648-8607

Research Summary

To decide between irreversible cell fates such as growth, differentiation or death, cells process information about their environment through a network of molecular circuits. Our research combines principles of systems and synthetic biology with large-scale data to understand how information flows through these circuits. By observing input-output relationships in the same cell using microfluidics, live-cell dynamics and single-molecule microscopy, we aim to decode the ‘language’ of signaling dynamics and develop mathematical models of information flow with single-cell resolution. Our ultimate goal is to understand how population-level responses emerge from single-cell heterogeneity and to rationally manipulate cell fate decisions in disease.

Recent Publications

Lee REC, Walker S, Savery K, Frank D and Gaudet S (2014) Fold-change of nuclear NF-κB determines TNF-induced transcription in single cells Molecular Cell, 53:6.

Xia X, Owen M, Lee REC and Gaudet S (2014) Cell-to-cell variability in cell death: can systems biology help us make sense of it all? Cell Death & Disease, (in press).

Shrestha A, Lee REC, Megeney LA (2014) Monitoring the proteostasis function of the Saccharomyces cerevisiae metacaspase Yca1. in press: Caspases, Paracaspases and Metacaspases (Methods in Molecular Biology), Ed. Peter Bozhkov, Humana Press USA, vol. 1133.