Qiuhong Zhang

Qiuhong Zhang, Ph.D.
Research Instructor

PhD in Pathology & Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan
Contact

3501 Fifth Avenue
Pittsburgh, PA 15260

Phone: 412-648-3333
E-mail: qiz15@pitt.edu

Research Summary

I earned my MD and Ph.D. degree in Pathology and Pathophysiology from Xiangya School of Medicine in China. After graduation, I joined the University of Pittsburgh focusing on the molecular mechanism of carcinogenesis, tumor biomarker discovery, and target drug screening. Currently, I am interested in how cellular information processing leads to different cell-fate decisions under cytokine stimulation. To study the dynamic regulation of signaling cascades of NF-kB pathway in single cells, I designed and established a series of single/double fluorescence labeling stable cell lines of interested proteins such as IKK and RelA by CRISPR/Cas9 genomic editing. Moreover, I detected and analyzed the quantitative single cell responses to inflammatory signals by conducting 2D/3D single live cell imaging. I am also involved in the image data analysis tool development and collaboration with a number of biologists to study a variety of crucial biological processes related to NF-kB pathway.

Recent Publications
Zhang Q, Gupta S, Schipper D, Kowalczyk G, Mancini A, Faeder J, Lee R (2017) NF-κB Dynamics Discriminate between TNF Doses in Single Cells. Cell Systems. 5(6): 638-645

Kang R, Xie YC, Zhang Q, Hou W, Jiang QP, Sun XF, Zeng DX, Wang HC, Bartlett D, Billiar TR, Lotze MT, Zeh HJ, Tang D (2017) Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer. Cell Res. 7: 916-932