Mark Schurdak

Mark E. Schurdak, Ph.D.
Visiting Research Associate Professor

Ph.D. in Pharmacology, Baylor College of Medicine
10045 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, Pennsylvania 15260Phone: 412-648-3090
Research Summary

My research interests center on applying a systems biology/pharmacology approach to develop more effective drug discovery strategies that utilize integrated phenotype/function-based analysis (where all targets involved are functioning in a more physiologic relevant environment) and to better understand the molecular mechanisms that cause drugs to succeed or fail in the clinic.

Recent Publications

Gough A, Shun T, Lansing Taylor D, Schurdak M. (2015) A Metric and Workflow for Quality Control in the Analysis of Heterogeneity in Phenotypic Profiles and Screens Methods S1046-2023(15)30126-2.

D’Aiuto L, Zhi Y, Das DK, Wilcox MR, Johnson JW, McClain L, MacDonald ML, Di Maio R, Schurdak ME, Piazza P, Viggiano L, Sweet R, Kinchington PR, Bhattacharjee AG, Yolken R, Nimgaonkar VL (2015) Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation Organogenesis 10(4): 365-77.

Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL (2014) Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery PLoS One 9(7):e102678.


Project title Proj Start Date Proj End Date Funding Source
Chemical Biology Consortium – Task Order 8: Administrative Support 02/24/2011 03/31/2016 NIH
Cancer Center Support Grant 08/01/2010 07/31/2016 NIH P30
Understudied orphan receptors – novel treatment targets in ovarian cancer 09/01/2013 8/31/2016 US Army
Acute Pancreatitis as a Model to Predict Transition of Systemic Inflammation to Organ Failure in Trauma and Critical Illness 09/01/2013 8/31/2016 US Army
Determining Mechanisms of Disease Progression using Quantitative Systems Pharmacology (QSP) 01/01/2015 12/31/2018 PA Dept of Health