DNA damage detection, repair, and signaling are some of the most conserved processes in biology, however, the response to and consequence of DNA damage varies greatly across cell types within our body.  Our goal is to understand how DNA damage is sensed, quantified and responded to by a cell and how these systems are tuned across cell types or species.  We use live cell imaging, genetic screens, genomic tools, and mathematical models to study the diversity of DNA damage signaling and to understand how this signaling might be manipulated to improve cancer therapy.

Stewart-Ornstein J, Cheng HWJ, Lahav G (2017) Conservation and Divergence of p53 Oscillation Dynamics across Species Cell Syst. Oct 25;5(4): 410-417

Stewart-Ornstein J, Lahav G (2017) Integrating genomic information and signaling dynamics for efficient cancer therapy Curr Opin Syst Biol. 2017 Feb;1: 38-43

Publications

Grants

Project title	Proj Start Date	Proj End Date	Funding Source