Ivet Bahar (Chair)

Ivet Bahar, Ph.D.
Distinguished Professor and John K. Vries Chair

Ph.D. in Chemistry, Istanbul Technical Institute; B.S. and M.S. in Chemical Engineering, Bogazici U.
Bahar

Contact

Assistant: Lauren Lamar
Phone: (412) 624-7615
Email: lal93@pitt.edu | bahar@pitt.edu
Website: /Faculty/bahar/index.php

3058 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15213

Research Summary

Our goal is to understand the functional dynamics of biological systems at the molecular level. To this aim (1) we develop theoretical and computational models (e.g., elastic network models) and methods that help understand the dynamics of molecular machines and membrane proteins, (2) use these approaches to advance knowledge of the molecular basis of protein-protein and protein-ligand interactions and their implications on cell signaling and apoptosis, and to identify pharmacological targets for controlling these mechanisms. We would like to (i) elucidate the mechanisms of molecular machinery and allostery using fundamental principles of statistical mechanics and biophysical chemistry, (ii) analyze the networks of interactions at the cellular level using engineering tools and concepts of chemical reaction kinetics, transport phenomena, and stochastics theory, (iii) utilize the reuslts from both groups of studies toward computer-aided drug discovery and (iv) translate our knowledge from molecular-to-cellular computational and/or theoretical studies to biomedical and clinical applications.

Recent Publications

Cheng MH, Torres-Salazar D, Gonzalez-Suarez AD, Amara SG, Bahar I (2017) Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters. eLife [Epub ahead of print].

Cheng MH, Garcia-Olivares J, Wasserman S, DiPietro J, Bahar I (2017) Allosteric Modulation of Human Dopamine Transporter Activity under Conditions Promoting its Dimerization J Biol Chem [Epub ahead of print].

Sauerwald N, Zhang S, Kingsford C, Bahar I. (2017) Chromosomal dynamics predicted by an elastic network model explains genome-wide accessibility and long-range couplings Nucleic Acids Research 45:3663-3673

Publications

Grants
Project title Proj Start Date Proj End Date Funding Source
NIDA Center of Excellence for Computational Drug Abuse Research (CDAR) 8/1/2014 7/31/2019 NIDA-P30
Continued Development of Protein Dynamics Software ProDy 3/26/2012 12/31/2016 NIGMS-R01
Center for Causal Modeling and Discovery of Biomedical Knowledge from Big Data-Training 9/29/2014 8/31/2018 NHGRI-U54
New Therapies for Liver Fibrosis and Hyperproliferation in Alpha 1-AT Deficiency 9/24/2012 8/31/2017 NIDDK-P01
Integrated Interdisciplinary, inter-university PhD Program Computational Biology (T32) 8/1/2014 7/31/2019 NIBIB-T32
Core E: Signature-Directed, Sequential Delivery of Radiation Mitigators CMCR 9/1/2010 8/31/2020 NIAID-U19
High Performance Computing for Multiscale Modeling of Biological Systems 9/24/2012 7/31/2017 NIGMS-P41