| June 1-6, 2014 Salve Regina University, Newport, RI | This Application has been closed. |
Biopolymers
Mechanisms of Biomolecular Interactions: From Physical Principles to Biological Insights
| Chair: | Vice Chair: |
| Ivet Bahar | Harald Schwalbe |
Application Deadline
Applications for this meeting must be submitted by May 4, 2014. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations. A preliminary program outline is available below. Additional speakers and discussion leaders will be selected from among the abstract submissions.
Summary
It is widely established that it is essential to understand the dynamics and mechanisms of biomolecular interactions in order to develop methods for efficiently monitoring biological activities, designing new functionalities or altering existing properties. Fundamental principles of physical sciences, polymer science and engineering have played a crucial role in molecular and structural biology in establishing the physical basis and origin of complex interactions. Significant advances have been made in recent years, both computationally and experimentally. However, the cooperative dynamics and evolutionary properties of biological systems, as well as the effect of the physiological (crowded) environment present additional layers of complexity, which are limiting our ability to elucidate the mechanisms of function and allostery that underlie many observed phenomena. These complications are best reflected in the characterization of membrane proteins and biomolecular machines often composed of multiple subunits that act concertedly in restricting environments. The development of effective strategies for identifying the molecular origin and mechanisms of observed phenomena and for developing intervention methods for regulating or modifying biological function requires a deeper level of quantitative investigation and multidisciplinary collaboration. The proposed GRC is uniquely poised to bring together scientists from different disciplines and foster new collaborations toward this aim.
Preliminary Program
- Keynote Session: Biomolecular Machinery, Signaling and Regulation
(Harald Schwalbe / John Kuriyan / Andrej Sali) - Biomolecular Complex Formation, Oligomerization and Assembly
(Shoshana Wodak / Gidon Schreiber / Holger Stark / Sarah Woodson) - Structural Dynamics of Membrane Proteins: From Single Molecules to Cell Interactions
(Benoit Roux / TBA / Tamir Gonen) - Membrane Transport: Structures, Dynamics and Mechanisms
(Gary Rudnick / Lucy Forrest / TBA / Olga Boudker) - Allosteric Modulation of Function by Substrate / Ligand Binding
(Adrian Elcock / Poul Nissen / Stephen Blacklow) - Protein-Drug Interactions: From Molecular Docking to Systems Pharmacology
(Andy McCammon / Brian Shoichet / TBA) - Detection of Conformational Changes
(TBA / Robert Sauer/Yann Chemla) - Design and Evolution
(TBA / Tanja Kortemme / Sarah Teichmann / Nikolay Dokholyan) - Misfolding and Aggregation
(Teresa Head-Gordon / John Straub / Patricia Clark)