Evolutionary Rate Covariation (ERC)
Genes that function in a common pathway or complex exihibit signatures of co-evolution. We identify and exploit these signatures to infer new genetic interactions and reveal deeper relationships between entire genetic pathways. To date we have performed genome-wide coevolution studies in yeasts, Drosophila, and mammalian species, in each case providing insight into gene function.
Perform custom ERC analyses on any genes through our public webserver.
Active lab members: Zelia Ferreira, Nick Wolfe, Charles Kronk