An interview with Assistant Professor Mary Cheng, on her recent work on dopamine transporter dynamics, was published by Cell Press, highlighting her recent paper paper published in Structure (see Cheng MH, Bahar I (2015) Molecular Mechanism of Dopamine Transport by Human Dopamine Transporter Structure pii: S0969-2126).
Dr. Bing Liu gave a poster presentation at the Postdoctoral Data & Dine Symposium on Tuesday, May 19, 2015 and won a $500 travel award. He presented his work on "TLR3-TLR7 pathway crosswalk confers innate immune memory and homeostasis."
Two outstanding Tsinghua University Research Scholars, Feizhuo Kaitlyn Hu and Wenzhi Mao have returned to their home institutions after successfully completing extensive research, resulting in several publications in the Bahar Lab. We wish them continued success on their scientific journeys!
Anindita Dutta's recent award for the "Outstanding Student Researcher in the Department of Computational & Systems Biology of 2012".
Lidio was first author on the Protein Science article that became the cover of the September 2011 issue, "Pre-existing soft modes of motion uniquely defined by native contact topology facilitate ligand binding to proteins", along with lab members Dr. Mert Gur, Dr. Ahmet Bakan, and Dr. Ivet Bahar.
Ahmet Bakan's recent PNAS paper on drug binding mechanisms vs. intrinsic changes in shape(PDF).
See also his paper: "In vivo chemical screen in zebrafish reveals a novel modulator of FGF signaling"
and related commentaries: " Small molecule inhibitors: Another one bites the Dusp."
Dr. Lee Wei Yang, a former graduate student has recieved the Stephen L. Phillips Award
(click to see full image) "2007 Outstanding Student Researcher Award" : Basak Isin
Former student Lee-Wei Yang published article in Pitt magazine " Investigations: Explorations and revalations taking place in the medical school"
"Coupled Global and Local Changes Direct Substrate Translocation by Neurotransmitter-Sodium Symporter Ortholog LeuT" Cheng MH, Bahar I (2013) Biophys J. 105:630-639. PMID: 23931311
This is a first attempt to complete the molecular description of all steps involved in LeuT transport cycle. Notably, the secondary substrate-binding site S2, the functional relevance of which has been debated, appears to stably bind an alanine only when the transporter assumes an intermediate conformer close to inward-facing state.
"Protonation of Glutamate-208 Induces the Release of Agmatine in an Outward-Facing Conformation of Arginine/Agmatine Antiporter." Zomot E, Bahar I. (2011) J Biol Chem. 286:19693-701. PMID: 21487006
"Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter." Gu Y, Shrivastava IH, Amara SG, Bahar I. (2009) Proc Natl Acad Sci U S A. 106:2589-94