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Distinguished Speaker – Dr. Nevan Krogan, Department of Cellular and Molecular Pharmacology, UCSF

When:
January 31, 2017 @ 4:00 pm – 5:00 pm
2017-01-31T16:00:00-05:00
2017-01-31T17:00:00-05:00
Where:
ROOM 6014 BST3 (BIOMEDICAL SCIENCE TOWER 3)

Tuesday, January 31, 2017 @ 4 pm in 6014 BST3 (talk title and abstract below)
The Department of Computational and System Biology

Dr. Nevan Krogan
Professor, Cellular and Molecular Pharmacology
Director, QBI-Quantitative Bioscience Institute
Senior Investigator, J. Gladstone institute
University of California, San Francisco

From Systems to Structure: Bridging Networks and Mechanism

ABSTRACT:

There is a wide gap between the generation of large-scale biological data sets and more-detailed, structural and mechanistic studies. However, recent work that explicitly combine data from systems and structural biological approaches is having a profound effect on our ability to predict how mutations and small molecules affect atomic-level mechanisms, disrupt systems-level networks and ultimately lead to changes in organismal fitness. Our group aims to create a stronger bridge between these areas primarily using three types of data: genetic interactions, protein-protein interactions and post-translational modifications. Protein structural information helps to prioritize and functionally understand these large-scale datasets; conversely global, unbiasedly collected datasets helps inform the more mechanistic studies. Our efforts in this respect are presently focused on model organisms, including yeast and bacteria, as well as in mammalian cells, with a particular focus on pathogenesis.

Sandra D. Yates
Administrative Assistant/Office Coordinator
Department of Computational and Systems Biology
University of Pittsburgh School of Medicine
3064 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15260
Tel: (412) 648-3333
Fax (412) 648-3163
Email: sdyates@pitt.edu

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