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Summary of Research
The interface between biology and physics currently resides at the level of macromolecules and their complexes: Direct application of the canonical laws of physics does not satisfactorily describe much of the general behavior of molecular-level biological systems. Our understanding of topics such as protein folding and function, dynamics of molecular complexes and behavior of systems of interacting molecules can be enhanced through new formalisms of the physical laws of biology. I am interested primarily in using coarse-grained models and statistical physics techniques to elucidate the underlying physical rules that are applied to the elements of living systems.
Timothy Lezon
Assistant Professor
Website: www.csb.pitt.edu/faculty/lezon/

Research Area
Protein dynamics, Systems biology
Recent Publications

Bahar I, Lezon TR, Bakan A and Shrivastava IH. Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins. Chem Rev 110:1463-1497 (2010).


Bahar I, Lezon TR, Yang L-W and Eyal E. Global dynamics of proteins: Bridging between structure and function. Ann Rev Biophys 39:23-32 (2010).


Lezon TR, Sali A and Bahar I. Global motions of the nuclear pore complex: insights from elastic network models. PLoS Comp Biol 5: e1000496 (2009).


Awards and Honors
Contact


Phone: (412) 383-5743
E-mail:
Website: www.csb.pitt.edu/faculty/lezon/

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